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The authors of this work, in previous studies, have applied a systems biology approach to develop a methodology that enables the identification, aggregation, and integration of the signaling cascades at the cellular level to develop molecular systems architectures

however, drug resistance limits its effectiveness and is a major cause of recurrence and poor prognosis in PDAC patients

The pathophysiology of abdominal pain in IBS-C and FC is complex and multifactorial, involving a variety of crosstalk mechanisms that contribute to the severity and recurrent of symptoms

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[45] High level of IGF1 in acromegaly is related to an increased risk of some cancers, particularly colon cancer and thyroid cancer